Title |
Review of juxtaglomerular cell tumor with focus on pathobiological aspect
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Published in |
Diagnostic Pathology, August 2011
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DOI | 10.1186/1746-1596-6-80 |
Pubmed ID | |
Authors |
Naoto Kuroda, Hiroko Gotoda, Chisato Ohe, Shuji Mikami, Keiji Inoue, Yoji Nagashima, Fredrik Petersson, Isabel Alvarado-Cabrero, Chin-Chen Pan, Ondrej Hes, Michal Michal, Zoran Gatalica |
Abstract |
Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 18% |
Researcher | 5 | 13% |
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Student > Bachelor | 3 | 8% |
Lecturer | 2 | 5% |
Other | 10 | 26% |
Unknown | 9 | 23% |
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Arts and Humanities | 2 | 5% |
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Unspecified | 1 | 3% |
Other | 2 | 5% |
Unknown | 12 | 31% |