Chapter title |
Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function
|
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Chapter number | 58 |
Book title |
Free Fatty Acid Receptors
|
Published in |
Handbook of experimental pharmacology, October 2016
|
DOI | 10.1007/164_2016_58 |
Pubmed ID | |
Book ISBNs |
978-3-31-950692-0, 978-3-31-950693-7
|
Authors |
Hudson, Brian D, Brian D. Hudson, Hudson, Brian D. |
Editors |
Graeme Milligan, Ikuo Kimura |
Abstract |
The free fatty acid (FFA) family of G protein coupled receptors (GPCRs) has generated significant interest for exploiting its members as potential drug targets. However, unravelling the complex pharmacology of this family of receptors has proven challenging. In recent years the use of biosensor technologies capable of assessing biological functions in living cells, and in real time, has greatly enhanced our ability to study GPCR pharmacology and function. These include genetically encoded sensors that change the intensity or wavelength of light emitted from a bioluminescent or fluorescent protein in response to a stimulus, as well as non-genetically encoded sensors able to measure more global cellular changes, such as mass redistribution within a cell. This chapter will examine how these sensors can be used to study GPCRs, and in particular how they are helping uncover the pharmacology of the FFA family of receptors. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 33% |
Student > Master | 3 | 25% |
Other | 2 | 17% |
Student > Postgraduate | 1 | 8% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 25% |
Medicine and Dentistry | 1 | 8% |
Engineering | 1 | 8% |
Unknown | 2 | 17% |