Title |
Bee venom effects on ubiquitin proteasome system in hSOD1G85R-expressing NSC34 motor neuron cells
|
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Published in |
BMC Complementary Medicine and Therapies, July 2013
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DOI | 10.1186/1472-6882-13-179 |
Pubmed ID | |
Authors |
Seon Hwy Kim, So Young Jung, Kang-Woo Lee, Sun Hwa Lee, MuDan Cai, Sun-Mi Choi, Eun Jin Yang |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results from a progressive loss of motor neurons. Familial ALS (fALS) is caused by missense mutations in Cu, Zn-superoxide dismutase 1 (SOD1) that frequently result in the accumulation of mutant-protein aggregates that are associated with impairments in the ubiquitin-proteasome system (UPS). UPS impairment has been implicated in many neurological disorders. Bee venom (BV) extracted from honey bees has been used as a traditional medicine for treating inflammatory diseases and has been shown to attenuate the neuroinflammatory events that occur in a symptomatic ALS animal model. |
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United States | 2 | 67% |
Spain | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 33% |
Student > Master | 9 | 25% |
Student > Bachelor | 5 | 14% |
Researcher | 3 | 8% |
Student > Doctoral Student | 3 | 8% |
Other | 2 | 6% |
Unknown | 2 | 6% |
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Neuroscience | 6 | 17% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 4 | 11% |
Unknown | 5 | 14% |