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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E

Overview of attention for article published in Nature, May 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Average Attention Score compared to outputs of the same age and source

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Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
Published in
Nature, May 2002
DOI 10.1038/417299a
Pubmed ID

Molly Duman-Scheel, Li Weng, Shijie Xin, Wei Du


Although mutations that activate the Hedgehog (Hh) signalling pathway have been linked to several types of cancer, the molecular and cellular basis of Hh's ability to induce tumour formation is not well understood. We identified a mutation in patched (ptc), an inhibitor of Hh signalling, in a genetic screen for regulators of the Retinoblastoma (Rb) pathway in Drosophila. Here we show that Hh signalling promotes transcription of Cyclin E and Cyclin D, two inhibitors of Rb, and principal regulators of the cell cycle during development in Drosophila. Upregulation of Cyclin E expression, accomplished through binding of Cubitus interruptus (Ci) to the Cyclin E promoter, mediates the ability of Hh to induce DNA replication. Upregulation of Cyclin D expression by Hh mediates the distinct ability of Hh to promote cellular growth. The discovery of a direct connection between Hh signalling and principal cell-cycle regulators provides insight into the mechanism by which deregulated Hh signalling promotes tumour formation.

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Canada 1 <1%
United Kingdom 1 <1%
Japan 1 <1%
Germany 1 <1%
Unknown 99 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 30%
Student > Ph. D. Student 19 18%
Professor 10 10%
Student > Master 10 10%
Student > Bachelor 8 8%
Other 17 16%
Unknown 9 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 50%
Biochemistry, Genetics and Molecular Biology 23 22%
Medicine and Dentistry 12 11%
Chemistry 2 2%
Psychology 1 <1%
Other 3 3%
Unknown 11 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2009.
All research outputs
of 9,930,310 outputs
Outputs from Nature
of 52,568 outputs
Outputs of similar age
of 9,282,085 outputs
Outputs of similar age from Nature
of 51,956 outputs
Altmetric has tracked 9,930,310 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 52,568 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 76.6. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 9,282,085 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 51,956 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.