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Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)

Overview of attention for article published in PLoS Neglected Tropical Diseases, July 2013
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1 Facebook page

Citations

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10 Dimensions

Readers on

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16 Mendeley
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Title
Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)
Published in
PLoS Neglected Tropical Diseases, July 2013
DOI 10.1371/journal.pntd.0002306
Pubmed ID
Authors

Liesbeth M. Kager, Marcel Schouten, W. Joost Wiersinga, J. Daan de Boer, Lionel C. W. Lattenist, Joris J. T. H. Roelofs, Joost C. M. Meijers, Marcel Levi, Arjen M. Dondorp, Charles T. Esmon, Cornelis van 't Veer, Tom van der Poll

Abstract

The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. We studied the role of EPCR in the host response during pneumonia-derived sepsis instigated by Burkholderia (B.) pseudomallei, the causative agent of melioidosis, a common form of community-acquired Gram-negative (pneumo)sepsis in South-East Asia.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ethiopia 1 6%
Thailand 1 6%
Malaysia 1 6%
Unknown 13 81%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 19%
Student > Bachelor 2 13%
Student > Master 2 13%
Student > Ph. D. Student 2 13%
Researcher 2 13%
Other 5 31%
Readers by discipline Count As %
Unspecified 5 31%
Agricultural and Biological Sciences 5 31%
Medicine and Dentistry 3 19%
Biochemistry, Genetics and Molecular Biology 1 6%
Nursing and Health Professions 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2013.
All research outputs
#2,903,183
of 3,628,563 outputs
Outputs from PLoS Neglected Tropical Diseases
#1,974
of 2,213 outputs
Outputs of similar age
#68,502
of 85,779 outputs
Outputs of similar age from PLoS Neglected Tropical Diseases
#115
of 130 outputs
Altmetric has tracked 3,628,563 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,213 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 85,779 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.