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Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Overview of attention for article published in Cell, April 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Citations

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446 Dimensions

Readers on

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231 Mendeley
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Title
Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex
Published in
Cell, April 2002
DOI 10.1016/s0092-8674(02)00679-7
Pubmed ID
Authors

Thomas Kramps, Oliver Peter, Erich Brunner, Denise Nellen, Barbara Froesch, Sandipan Chatterjee, Maximilien Murone, Stephanie Züllig, Konrad Basler

Abstract

Wnt/Wingless signaling controls many fundamental processes during animal development. Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors. Here we report the identification of two segment polarity genes in Drosophila, legless (lgs), and pygopus (pygo), and we show that their products are required for Wnt signal transduction at the level of nuclear beta-catenin. Lgs encodes the homolog of human BCL9, and we provide genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin. Our results suggest that the recruitment of Pygo permits beta-catenin to transcriptionally activate Wnt target genes and raise the possibility that a deregulation of these events may play a causal role in the development of B cell malignancies.

Mendeley readers

The data shown below were compiled from readership statistics for 231 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Spain 2 <1%
Russia 2 <1%
United Kingdom 1 <1%
Brazil 1 <1%
China 1 <1%
Pakistan 1 <1%
Switzerland 1 <1%
Germany 1 <1%
Other 0 0%
Unknown 217 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 29%
Researcher 48 21%
Student > Master 38 16%
Student > Doctoral Student 17 7%
Professor > Associate Professor 14 6%
Other 31 13%
Unknown 16 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 114 49%
Biochemistry, Genetics and Molecular Biology 60 26%
Medicine and Dentistry 18 8%
Chemistry 5 2%
Neuroscience 5 2%
Other 11 5%
Unknown 18 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2018.
All research outputs
#1,164,572
of 13,494,757 outputs
Outputs from Cell
#3,814
of 14,727 outputs
Outputs of similar age
#1,123,886
of 12,833,801 outputs
Outputs of similar age from Cell
#3,814
of 14,724 outputs
Altmetric has tracked 13,494,757 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,727 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.6. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,833,801 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 14,724 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.