Title |
MetaTopics: an integration tool to analyze microbial community profile by topic model
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Published in |
BMC Genomics, January 2017
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DOI | 10.1186/s12864-016-3257-2 |
Pubmed ID | |
Authors |
Jifang Yan, Guohui Chuai, Tao Qi, Fangyang Shao, Chi Zhou, Chenyu Zhu, Jing Yang, Yifei Yu, Cong Shi, Ning Kang, Yuan He, Qi Liu |
Abstract |
Deciphering taxonomical structures based on high dimensional sequencing data is still challenging in metagenomics study. Moreover, the common workflow processed in this field fails to identify microbial communities and their effect on a specific disease status. Even the relationships and interactions between different bacteria in a microbial community keep unknown. MetaTopics can efficiently extract the latent microbial communities which reflect the intrinsic relations or interactions among several major microbes. Furthermore, a quantitative measurement, Quetelet Index, is defined to estimate the influence of a latent sub-community on a certain disease status for given samples. An analysis of our in-house oral metagenomics data and public gut microbe data was presented to demonstrate the application and usefulness of MetaTopics. To preset a user-friendly R package, we have built a dedicated website, https://github.com/bm2-lab/MetaTopics , which includes free downloads, detailed tutorials and illustration examples. MetaTopics is the first interactive R package to integrate the state-of-arts topic model derived from statistical learning community to analyze and visualize the metagenomics taxonomy data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 3% |
United States | 1 | 2% |
Unknown | 59 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 19% |
Student > Bachelor | 11 | 18% |
Student > Master | 9 | 15% |
Researcher | 8 | 13% |
Student > Doctoral Student | 5 | 8% |
Other | 10 | 16% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 18 | 29% |
Computer Science | 12 | 19% |
Agricultural and Biological Sciences | 10 | 16% |
Medicine and Dentistry | 5 | 8% |
Immunology and Microbiology | 3 | 5% |
Other | 7 | 11% |
Unknown | 7 | 11% |