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The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states

Overview of attention for article published in Nature Structural Biology, February 2002
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Summary Research highlights Dimensions citations
Title
The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states
Published in
Nature Structural Biology, February 2002
DOI 10.1038/nsb767
Pubmed ID
11850638
Authors

Jun Y. Fan, Faye Gordon, Karolin Luger, Jeffrey C. Hansen, David John Tremethick

Abstract

Explaining the determinants involved in regulating the equilibrium between different chromatin structural states is fundamental to understanding differential gene expression. Histone variant H2A.Z is essential to chromatin architecture in higher eukaryotes but its role has not yet been explained. We show here that H2A.Z facilitates the intramolecular folding of nucleosomal arrays while simultaneously inhibiting the formation of highly condensed structures that result from intermolecular association. This makes a case for H2A.Z playing a fundamental role in creating unique chromatin domains poised for transcriptional activation. These results provide new insights into understanding how chromatin fiber dynamics can be altered by core histone variants to potentially regulate genomic function.

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Mendeley readers

The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
Singapore 1 <1%
Netherlands 1 <1%
Spain 1 <1%
Germany 1 <1%
Unknown 116 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 35 28%
Student > Ph. D. Student 29 23%
Student > Master 20 16%
Professor > Associate Professor 9 7%
Student > Bachelor 8 6%
Other 17 14%
Unknown 6 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 79 64%
Biochemistry, Genetics and Molecular Biology 26 21%
Medicine and Dentistry 3 2%
Engineering 3 2%
Physics and Astronomy 3 2%
Other 5 4%
Unknown 5 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2002.
All research outputs
#7,717,609
of 12,343,748 outputs
Outputs from Nature Structural Biology
#422
of 491 outputs
Outputs of similar age
#7,415,757
of 11,735,851 outputs
Outputs of similar age from Nature Structural Biology
#423
of 492 outputs
Altmetric has tracked 12,343,748 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 491 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,735,851 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 492 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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