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Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1

Overview of attention for article published in Aging, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 1,968)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
78 news outlets
blogs
1 blog
twitter
6 tweeters
facebook
3 Facebook pages
wikipedia
1 Wikipedia page
googleplus
3 Google+ users
reddit
2 Redditors
video
2 video uploaders

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
56 Mendeley
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Title
Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1
Published in
Aging, February 2017
DOI 10.18632/aging.101174
Pubmed ID
Authors

Irina G. Shabalina, Mikhail Yu. Vyssokikh, Natalia Gibanova, Robert I. Csikasz, Daniel Edgar, Anne Hallden-Waldemarson, Zinaida Rozhdestvenskaya, Lora E. Bakeeva, Valeria B. Vays, Antonina V. Pustovidko, Maxim V. Skulachev, Barbara Cannon, Vladimir P. Skulachev, Jan Nedergaard

Abstract

MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant SkQ1 showed a delayed appearance of traits of aging such as kyphosis, alopecia, lowering of body temperature, body weight loss, as well as ameliorated heart, kidney and liver pathologies. These effects of SkQ1 are suggested to be related to an alleviation of the effects of an enhanced reactive oxygen species (ROS) level in mtDNA mutator mice: the increased mitochondrial ROS released due to mitochondrial mutations probably interact with polyunsaturated fatty acids in cardiolipin, releasing malondialdehyde and 4-hydroxynonenal that form protein adducts and thus diminishes mitochondrial functions. SkQ1 counteracts this as it scavenges mitochondrial ROS. As the results, the normal mitochondrial ultrastructure is preserved in liver and heart; the phosphorylation capacity of skeletal muscle mitochondria as well as the thermogenic capacity of brown adipose tissue is also improved. The SkQ1-treated mice live significantly longer (335 versus 290 days). These data may be relevant in relation to treatment of mitochondrial diseases particularly and the process of aging in general.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Russia 1 2%
Romania 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 27%
Student > Ph. D. Student 10 18%
Professor > Associate Professor 6 11%
Student > Master 6 11%
Student > Bachelor 6 11%
Other 11 20%
Unknown 2 4%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 32%
Agricultural and Biological Sciences 14 25%
Medicine and Dentistry 5 9%
Neuroscience 4 7%
Chemistry 2 4%
Other 7 13%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 625. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2019.
All research outputs
#16,073
of 16,109,166 outputs
Outputs from Aging
#3
of 1,968 outputs
Outputs of similar age
#594
of 262,631 outputs
Outputs of similar age from Aging
#1
of 37 outputs
Altmetric has tracked 16,109,166 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,968 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,631 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.