Title |
The role of actin in capacitation-related signaling: an in silico and in vitro study
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Published in |
BMC Systems Biology, March 2011
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DOI | 10.1186/1752-0509-5-47 |
Pubmed ID | |
Authors |
Nicola Bernabò, Paolo Berardinelli, Annunziata Mauro, Valentina Russo, Pia Lucidi, Mauro Mattioli, Barbara Barboni |
Abstract |
The signalling cascades involved in many biological processes require the coordination of different subcellular districts. It is the case of the pathways involved in spermatozoa acquisition of fertilizing ability (the so called "capacitation"). In the present work the coordination of subcellular signalling, during the boar sperm capacitation, was studied by a computational and experimental approach. As first the biological network representing all the molecular interactions involved in capacitation was build and analyzed, then, an experimental set up was carried out to confirm the computational model-based prediction. |
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Demographic breakdown
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