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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding
|
|---|---|
| Published in |
Retrovirology, July 2013
|
| DOI | 10.1186/1742-4690-10-79 |
| Pubmed ID | |
| Authors |
Paola Sette, Kunio Nagashima, Robert C Piper, Fadila Bouamr |
| Abstract |
HIV-1 relies on the host ESCRTs for release from cells. HIV-1 Gag engages ESCRTs by directly binding TSG101 or Alix. ESCRTs also sort ubiquitinated membrane proteins through endosomes to facilitate their lysosomal degradation. The ability of ESCRTs to recognize and process ubiquitinated proteins suggests that ESCRT-dependent viral release may also be controlled by ubiquitination. Although both Gag and ESCRTs undergo some level of ubiquitination, definitive demonstration that ubiquitin is required for viral release is lacking. Here we suppress ubiquitination at viral budding sites by fusing the catalytic domain of the Herpes Simplex UL36 deubiquitinating enzyme (DUb) onto TSG101, Alix, or Gag. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 37% |
| Student > Bachelor | 10 | 12% |
| Researcher | 8 | 10% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 6 | 7% |
| Unknown | 16 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 31% |
| Agricultural and Biological Sciences | 19 | 23% |
| Immunology and Microbiology | 9 | 11% |
| Medicine and Dentistry | 3 | 4% |
| Veterinary Science and Veterinary Medicine | 2 | 2% |
| Other | 5 | 6% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2016.
All research outputs
#8,261,756
of 25,373,627 outputs
Outputs from Retrovirology
#437
of 1,273 outputs
Outputs of similar age
#68,365
of 209,985 outputs
Outputs of similar age from Retrovirology
#10
of 24 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 209,985 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.