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A functional genomic perspective on human well-being

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, July 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
35 news outlets
blogs
18 blogs
policy
2 policy sources
twitter
169 tweeters
peer_reviews
1 peer review site
facebook
57 Facebook pages
wikipedia
1 Wikipedia page
googleplus
15 Google+ users
reddit
3 Redditors

Citations

dimensions_citation
211 Dimensions

Readers on

mendeley
600 Mendeley
citeulike
5 CiteULike
Title
A functional genomic perspective on human well-being
Published in
Proceedings of the National Academy of Sciences of the United States of America, July 2013
DOI 10.1073/pnas.1305419110
Pubmed ID
Authors

B. L. Fredrickson, K. M. Grewen, K. A. Coffey, S. B. Algoe, A. M. Firestine, J. M. G. Arevalo, J. Ma, S. W. Cole

Abstract

To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-κB and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.

Twitter Demographics

The data shown below were collected from the profiles of 169 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 600 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 24 4%
Germany 4 <1%
United Kingdom 4 <1%
Australia 3 <1%
France 3 <1%
Switzerland 2 <1%
New Zealand 2 <1%
South Africa 2 <1%
Sweden 2 <1%
Other 6 1%
Unknown 548 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 125 21%
Researcher 125 21%
Student > Master 79 13%
Student > Doctoral Student 46 8%
Professor 44 7%
Other 181 30%
Readers by discipline Count As %
Psychology 240 40%
Agricultural and Biological Sciences 92 15%
Unspecified 62 10%
Medicine and Dentistry 47 8%
Social Sciences 42 7%
Other 117 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 595. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2019.
All research outputs
#11,504
of 13,501,776 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#403
of 80,360 outputs
Outputs of similar age
#98
of 155,546 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#9
of 909 outputs
Altmetric has tracked 13,501,776 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,360 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,546 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 909 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.