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Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face

Overview of attention for article published in Anais Brasileiros de Dermatologia, October 2016
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Title
Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face
Published in
Anais Brasileiros de Dermatologia, October 2016
DOI 10.1590/abd1806-4841.20165077
Pubmed ID
Authors

Águida Cristina Gomes Henriques, Roseana de Almeida Freitas, Bruno Cunha Pires, Clarissa Araújo Gurgel, Jean Nunes dos Santos

Abstract

The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. The aim of this study was to evaluate the participation of mast cells, elastin and collagen in a series of oral fibromas and fibrous papules of the face in order to better understand the possible role of these factors in fibrosis and the formation of these lesions. Thirty cases of oral fibroma involving the buccal mucosa and 30 cases of fibrous papules of the face were selected. Tissue samples were submitted to picrosirius red staining and immunohistochemistry using anti-elastin and anti-tryptase antibodies. The percentage of tryptase-positive mast cells and expression of elastin were higher in cases of fibrous papules of the face (p < 0.05). In contrast, a higher intensity of collagen deposition was observed in oral fibromas. The results showed mast cell accumulation and higher elastin synthesis in fibrous papules of the face, and mast cell accumulation with higher collagen fiber synthesis in oral fibromas. These findings support the hypothesis that mast cells influence the development and growth of these lesions through different mechanisms.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 29%
Student > Ph. D. Student 1 14%
Unknown 4 57%
Readers by discipline Count As %
Medicine and Dentistry 2 29%
Unknown 5 71%