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Some Oral Poliovirus Vaccines Were Contaminated with Infectious SV40 after 1961

Overview of attention for article published in Cancer Research, November 2005
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
4 news outlets
twitter
135 tweeters
patent
1 patent
facebook
22 Facebook pages
googleplus
3 Google+ users

Citations

dimensions_citation
91 Dimensions

Readers on

mendeley
36 Mendeley
citeulike
1 CiteULike
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Title
Some Oral Poliovirus Vaccines Were Contaminated with Infectious SV40 after 1961
Published in
Cancer Research, November 2005
DOI 10.1158/0008-5472.can-05-2028
Pubmed ID
Authors

Rochelle Cutrone, John Lednicky, Glynis Dunn, Paola Rizzo, Maurizio Bocchetta, Konstantin Chumakov, Philip Minor, Michele Carbone

Abstract

Some polio vaccines prepared from 1954 to 1961 were contaminated with infectious SV40. It has been assumed that all polio vaccines were SV40 free in the United States after 1961 and in other countries after 1962. Following a WHO requirement that was prompted by the detection of SV40 in some human tumors, we conducted a multilaboratory study to test for SV40 polio vaccines prepared after 1961. Vaccine samples from 13 countries and the WHO seed were initially tested by PCR. The possible presence of intact and/or infectious SV40 DNA in PCR-positive samples was tested by transfection and infection of permissive CV-1 cells. All results were verified by immunohistochemistry, cloning, and sequencing. All the vaccines were SV40 free, except for vaccines from a major eastern European manufacturer that contained infectious SV40. We determined that the procedure used by this manufacturer to inactivate SV40 in oral poliovirus vaccine seed stocks based on heat inactivation in the presence of MgCl2 did not completely inactivate SV40. These SV40-contaminated vaccines were produced from early 1960s to about 1978 and were used throughout the world. Our findings underscore the potential risks of using primary monkey cells for preparing poliovirus vaccines, because of the possible contamination with SV40 or other monkey viruses, and emphasize the importance of using well-characterized cell substrates that are free from adventitious agents. Moreover, our results indicate possible geographic differences in SV40 exposure and offer a possible explanation for the different percentage of SV40-positive tumors detected in some laboratories.

Twitter Demographics

The data shown below were collected from the profiles of 135 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Researcher 7 19%
Student > Bachelor 4 11%
Student > Master 4 11%
Student > Doctoral Student 2 6%
Other 2 6%
Unknown 7 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 31%
Agricultural and Biological Sciences 8 22%
Medicine and Dentistry 5 14%
Computer Science 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 8%
Unknown 6 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 140. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2022.
All research outputs
#226,040
of 21,765,082 outputs
Outputs from Cancer Research
#107
of 17,492 outputs
Outputs of similar age
#1,618
of 176,426 outputs
Outputs of similar age from Cancer Research
#1
of 179 outputs
Altmetric has tracked 21,765,082 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,492 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 179 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.