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Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis

Overview of attention for article published in BMC Infectious Diseases, July 2013
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Title
Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
Published in
BMC Infectious Diseases, July 2013
DOI 10.1186/1471-2334-13-358
Pubmed ID
Authors

Madelijn Geldhoff, Barry B Mook-Kanamori, Matthijs C Brouwer, Dirk Troost, Jaklien C Leemans, Richard A Flavell, Arie Van der Ende, Tom Van der Poll, Diederik Van de Beek

Abstract

Inflammasomes are multi-protein intracellular signaling complexes that have recently been hypothesized to play a role in the regulation of the inflammation response. We studied associations between inflammasome-associated cytokines IL-1β and IL-18 in cerebrospinal fluid (CSF) of patients with bacterial meningitis and clinical outcome, and pneumococcal serotype. In a murine model of pneumococcal meningitis we examined the pathophysiological roles of two inflammasome proteins, NLRP3 (Nod-like receptor protein-3) and adaptor protein ASC (apoptosis-associated speck-like protein).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 8 15%
Student > Bachelor 6 11%
Student > Doctoral Student 4 7%
Other 4 7%
Other 11 20%
Unknown 11 20%
Readers by discipline Count As %
Medicine and Dentistry 12 22%
Agricultural and Biological Sciences 11 20%
Immunology and Microbiology 5 9%
Nursing and Health Professions 2 4%
Neuroscience 2 4%
Other 7 13%
Unknown 15 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2013.
All research outputs
#20,196,821
of 22,715,151 outputs
Outputs from BMC Infectious Diseases
#6,441
of 7,658 outputs
Outputs of similar age
#173,864
of 197,887 outputs
Outputs of similar age from BMC Infectious Diseases
#110
of 153 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,658 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,887 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 153 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.