Title |
Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis
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Published in |
BMC Infectious Diseases, July 2013
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DOI | 10.1186/1471-2334-13-358 |
Pubmed ID | |
Authors |
Madelijn Geldhoff, Barry B Mook-Kanamori, Matthijs C Brouwer, Dirk Troost, Jaklien C Leemans, Richard A Flavell, Arie Van der Ende, Tom Van der Poll, Diederik Van de Beek |
Abstract |
Inflammasomes are multi-protein intracellular signaling complexes that have recently been hypothesized to play a role in the regulation of the inflammation response. We studied associations between inflammasome-associated cytokines IL-1β and IL-18 in cerebrospinal fluid (CSF) of patients with bacterial meningitis and clinical outcome, and pneumococcal serotype. In a murine model of pneumococcal meningitis we examined the pathophysiological roles of two inflammasome proteins, NLRP3 (Nod-like receptor protein-3) and adaptor protein ASC (apoptosis-associated speck-like protein). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 2% |
Unknown | 53 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Researcher | 8 | 15% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 4 | 7% |
Other | 4 | 7% |
Other | 11 | 20% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 22% |
Agricultural and Biological Sciences | 11 | 20% |
Immunology and Microbiology | 5 | 9% |
Nursing and Health Professions | 2 | 4% |
Neuroscience | 2 | 4% |
Other | 7 | 13% |
Unknown | 15 | 28% |