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Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium

Overview of attention for article published in BMC Microbiology, July 2013
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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7 X users

Citations

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35 Dimensions

Readers on

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138 Mendeley
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Title
Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium
Published in
BMC Microbiology, July 2013
DOI 10.1186/1471-2180-13-170
Pubmed ID
Authors

Elli A Wright, Joanne L Fothergill, Steve Paterson, Michael A Brockhurst, Craig Winstanley

Abstract

Pseudomonas aeruginosa populations within the cystic fibrosis lung exhibit extensive phenotypic and genetic diversification. The resultant population diversity is thought to be crucial to the persistence of infection and may underpin the progression of disease. However, because cystic fibrosis lungs represent ecologically complex and hostile environments, the selective forces driving this diversification in vivo remain unclear. We took an experimental evolution approach to test the hypothesis that sub-inhibitory antibiotics can drive diversification of P. aeruginosa populations. Replicate populations of P. aeruginosa LESB58 were cultured for seven days in artificial sputum medium with and without sub-inhibitory concentrations of various clinically relevant antibiotics. We then characterised diversification with respect to 13 phenotypic and genotypic characteristics.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
France 1 <1%
Colombia 1 <1%
Spain 1 <1%
Belgium 1 <1%
Unknown 130 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 20%
Researcher 26 19%
Student > Master 19 14%
Student > Bachelor 17 12%
Student > Doctoral Student 10 7%
Other 19 14%
Unknown 20 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 30%
Medicine and Dentistry 21 15%
Immunology and Microbiology 18 13%
Biochemistry, Genetics and Molecular Biology 12 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 4%
Other 16 12%
Unknown 24 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2015.
All research outputs
#7,229,557
of 23,577,654 outputs
Outputs from BMC Microbiology
#795
of 3,260 outputs
Outputs of similar age
#60,796
of 199,675 outputs
Outputs of similar age from BMC Microbiology
#9
of 25 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,260 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,675 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.