Title |
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
|
---|---|
Published in |
Molecular Cancer, February 2017
|
DOI | 10.1186/s12943-017-0602-2 |
Pubmed ID | |
Authors |
Komal Qureshi-Baig, Pit Ullmann, Serge Haan, Elisabeth Letellier |
Abstract |
Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Luxembourg | 1 | <1% |
Unknown | 112 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 26% |
Researcher | 14 | 12% |
Student > Master | 13 | 12% |
Student > Bachelor | 7 | 6% |
Student > Doctoral Student | 6 | 5% |
Other | 16 | 14% |
Unknown | 28 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 28 | 25% |
Agricultural and Biological Sciences | 23 | 20% |
Medicine and Dentistry | 14 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Immunology and Microbiology | 2 | 2% |
Other | 9 | 8% |
Unknown | 32 | 28% |