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Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Overview of attention for article published in Molecular Cancer, February 2017
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1 tweeter

Citations

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33 Dimensions

Readers on

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76 Mendeley
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Title
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
Published in
Molecular Cancer, February 2017
DOI 10.1186/s12943-017-0602-2
Pubmed ID
Authors

Komal Qureshi-Baig, Pit Ullmann, Serge Haan, Elisabeth Letellier

Abstract

Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 29%
Researcher 11 14%
Student > Master 10 13%
Student > Bachelor 6 8%
Student > Doctoral Student 5 7%
Other 11 14%
Unknown 11 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 28%
Biochemistry, Genetics and Molecular Biology 20 26%
Medicine and Dentistry 10 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Chemistry 2 3%
Other 6 8%
Unknown 14 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2017.
All research outputs
#7,892,230
of 9,105,319 outputs
Outputs from Molecular Cancer
#679
of 818 outputs
Outputs of similar age
#215,982
of 255,347 outputs
Outputs of similar age from Molecular Cancer
#25
of 33 outputs
Altmetric has tracked 9,105,319 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 818 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.