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Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case–control study

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2017
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2 tweeters
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1 Facebook page

Citations

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2 Dimensions

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9 Mendeley
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Title
Gender differences in the association between <em>HTR2C</em> gene variants and suicidal behavior in a Mexican population: a case&ndash;control study
Published in
Neuropsychiatric Disease and Treatment, February 2017
DOI 10.2147/ndt.s122024
Pubmed ID
Authors

Gabriel Molina-Guzman, Thelma Beatriz González-Castro, Yazmín Hernandez-Díaz, Carlos Alfonso Tovilla-Zarate, Isela E Juárez-Rojop, Crystell Guadalupe Guzman-Priego, Alma Genis, Sherezada Pool García, Maria Lilia López-Narvaez, Jose Manuel Rodriguez-Perez

Abstract

The aim of this case-control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population. A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype. In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24-10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts. These findings suggest a possible risk factor of the HTR2C gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Librarian 1 11%
Other 1 11%
Professor 1 11%
Student > Ph. D. Student 1 11%
Student > Master 1 11%
Other 2 22%
Unknown 2 22%
Readers by discipline Count As %
Psychology 2 22%
Agricultural and Biological Sciences 1 11%
Immunology and Microbiology 1 11%
Social Sciences 1 11%
Medicine and Dentistry 1 11%
Other 1 11%
Unknown 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2017.
All research outputs
#7,853,849
of 12,517,383 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,405
of 2,120 outputs
Outputs of similar age
#147,133
of 252,217 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#55
of 97 outputs
Altmetric has tracked 12,517,383 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,120 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,217 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 97 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.