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Total synthesis and biological evaluation of (−)-atrop–abyssomicin C

Overview of attention for article published in Organic and Biomolecular Chemistry, January 2013
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Mentioned by

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2 tweeters

Citations

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24 Dimensions

Readers on

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26 Mendeley
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Title
Total synthesis and biological evaluation of (−)-atrop–abyssomicin C
Published in
Organic and Biomolecular Chemistry, January 2013
DOI 10.1039/c3ob40692j
Pubmed ID
Authors

Filip Bihelovic, Ivanka Karadzic, Radomir Matovic, Radomir N. Saicic

Abstract

Enantioselective synthesis of a marine antibiotic (-)-atrop-abyssomicin C was accomplished in 21 steps, in 1.8% overall yield (4%, based on the recovered starting material). The key steps of the synthesis are the formation of the functionalized cyclohexane core by an organocatalyzed Tsuji-Trost reaction, the formation of a tricyclic spirotetronate unit by a gold-catalyzed reaction sequence and the highly efficient eleven-membered ring closure by a Nozaki-Hiyama-Kishi reaction. Biological tests showed all abyssomicin derivatives to possess strong antibacterial activity against methicillin resistant S. aureus strains; however, they also proved to be cytotoxic, both to malignant and to normal somatic cells.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 38%
Student > Doctoral Student 4 15%
Student > Bachelor 3 12%
Researcher 2 8%
Student > Master 2 8%
Other 3 12%
Unknown 2 8%
Readers by discipline Count As %
Chemistry 16 62%
Biochemistry, Genetics and Molecular Biology 4 15%
Agricultural and Biological Sciences 2 8%
Medicine and Dentistry 1 4%
Social Sciences 1 4%
Other 0 0%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2013.
All research outputs
#8,293,071
of 13,232,055 outputs
Outputs from Organic and Biomolecular Chemistry
#2,562
of 3,778 outputs
Outputs of similar age
#82,533
of 155,800 outputs
Outputs of similar age from Organic and Biomolecular Chemistry
#18
of 29 outputs
Altmetric has tracked 13,232,055 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,778 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,800 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.