↓ Skip to main content

Functional outcome measures in a surgical model of hip osteoarthritis in dogs

Overview of attention for article published in Journal of Experimental Orthopaedics, August 2016
Altmetric Badge

Mentioned by

video
1 video uploader

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
30 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Functional outcome measures in a surgical model of hip osteoarthritis in dogs
Published in
Journal of Experimental Orthopaedics, August 2016
DOI 10.1186/s40634-016-0053-5
Pubmed ID
Authors

Dianne Little, Stephen Johnson, Jonathan Hash, Steven A. Olson, Bradley T. Estes, Franklin T. Moutos, B. Duncan X. Lascelles, Farshid Guilak

Abstract

The hip is one of the most common sites of osteoarthritis in the body, second only to the knee in prevalence. However, current animal models of hip osteoarthritis have not been assessed using many of the functional outcome measures used in orthopaedics, a characteristic that could increase their utility in the evaluation of therapeutic interventions. The canine hip shares similarities with the human hip, and functional outcome measures are well documented in veterinary medicine, providing a baseline for pre-clinical evaluation of therapeutic strategies for the treatment of hip osteoarthritis. The purpose of this study was to evaluate a surgical model of hip osteoarthritis in a large laboratory animal model and to evaluate functional and end-point outcome measures. Seven dogs were subjected to partial surgical debridement of cartilage from one femoral head. Pre- and postoperative pain and functional scores, gait analysis, radiographs, accelerometry, goniometry and limb circumference were evaluated through a 20-week recovery period, followed by histological evaluation of cartilage and synovium. Animals developed histological and radiographic evidence of osteoarthritis, which was correlated with measurable functional impairment. For example, Mankin scores in operated limbs were positively correlated to radiographic scores but negatively correlated to range of motion, limb circumference and 20-week peak vertical force. This study demonstrates that multiple relevant functional outcome measures can be used successfully in a large laboratory animal model of hip osteoarthritis. These measures could be used to evaluate relative efficacy of therapeutic interventions relevant to human clinical care.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Student > Master 4 13%
Researcher 3 10%
Student > Bachelor 3 10%
Professor > Associate Professor 2 7%
Other 8 27%
Unknown 3 10%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 10 33%
Medicine and Dentistry 6 20%
Nursing and Health Professions 2 7%
Engineering 2 7%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 4 13%
Unknown 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2019.
All research outputs
#12,717,212
of 14,386,904 outputs
Outputs from Journal of Experimental Orthopaedics
#72
of 90 outputs
Outputs of similar age
#221,886
of 259,122 outputs
Outputs of similar age from Journal of Experimental Orthopaedics
#1
of 1 outputs
Altmetric has tracked 14,386,904 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 90 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,122 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them