Title |
The complexity of NF-κB signaling in inflammation and cancer
|
---|---|
Published in |
Molecular Cancer, August 2013
|
DOI | 10.1186/1476-4598-12-86 |
Pubmed ID | |
Authors |
Bastian Hoesel, Johannes A Schmid |
Abstract |
The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and progression. During these latter processes NF-κB cooperates with multiple other signaling molecules and pathways. Prominent nodes of crosstalk are mediated by other transcription factors such as STAT3 and p53 or the ETS related gene ERG. These transcription factors either directly interact with NF-κB subunits or affect NF-κB target genes. Crosstalk can also occur through different kinases, such as GSK3-β, p38, or PI3K, which modulate NF-κB transcriptional activity or affect upstream signaling pathways. Other classes of molecules that act as nodes of crosstalk are reactive oxygen species and miRNAs. In this review, we provide an overview of the most relevant modes of crosstalk and cooperativity between NF-κB and other signaling molecules during inflammation and cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Hungary | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | <1% |
United Kingdom | 7 | <1% |
Brazil | 4 | <1% |
Spain | 3 | <1% |
Chile | 2 | <1% |
Germany | 2 | <1% |
Mexico | 2 | <1% |
Russia | 2 | <1% |
France | 2 | <1% |
Other | 17 | <1% |
Unknown | 2038 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 505 | 24% |
Student > Bachelor | 300 | 14% |
Student > Master | 292 | 14% |
Researcher | 196 | 9% |
Student > Doctoral Student | 129 | 6% |
Other | 257 | 12% |
Unknown | 408 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 497 | 24% |
Biochemistry, Genetics and Molecular Biology | 469 | 22% |
Medicine and Dentistry | 252 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 103 | 5% |
Immunology and Microbiology | 103 | 5% |
Other | 180 | 9% |
Unknown | 483 | 23% |