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XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells

Overview of attention for article published in Epigenetics & Chromatin, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

dimensions_citation
30 Dimensions

Readers on

mendeley
64 Mendeley
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Title
XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
Published in
Epigenetics & Chromatin, August 2013
DOI 10.1186/1756-8935-6-23
Pubmed ID
Authors

Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton, Carolyn J Brown

Abstract

The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis-localization, and requires a series of well-conserved tandem 'A' repeats for silencing. We previously described a human inducible XIST transgene that is capable of cis-localization and suppressing a downstream reporter gene in somatic cells, and have now leveraged these cells to dissect the sequences critical for XIST-dependent gene silencing in humans.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 28%
Student > Master 13 20%
Researcher 11 17%
Student > Bachelor 5 8%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 6 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 44%
Biochemistry, Genetics and Molecular Biology 21 33%
Medicine and Dentistry 5 8%
Veterinary Science and Veterinary Medicine 1 2%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 7 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2014.
All research outputs
#707,432
of 6,792,436 outputs
Outputs from Epigenetics & Chromatin
#51
of 213 outputs
Outputs of similar age
#14,222
of 123,099 outputs
Outputs of similar age from Epigenetics & Chromatin
#3
of 7 outputs
Altmetric has tracked 6,792,436 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 213 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,099 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.