Title |
Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity
|
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Published in |
Current Obesity Reports, February 2017
|
DOI | 10.1007/s13679-017-0247-x |
Pubmed ID | |
Authors |
Clare H. Llewellyn, Alison Fildes |
Abstract |
There is considerable variability in human body weight, despite the ubiquity of the 'obesogenic' environment. Human body weight has a strong genetic basis and it has been hypothesised that genetic susceptibility to the environment explains variation in human body weight, with differences in appetite being implicated as the mediating mechanism; so-called 'behavioural susceptibility theory' (BST), first described by Professor Jane Wardle. This review summarises the evidence for the role of appetite as a mediator of genetic risk of obesity. Variation in appetitive traits is observable from infancy, drives early weight gain and is highly heritable in infancy and childhood. Obesity-related common genetic variants identified through genome-wide association studies show associations with appetitive traits, and appetite mediates part of the observed association between genetic risk and adiposity. Obesity results from an interaction between genetic susceptibility to overeating and exposure to an 'obesogenic' food environment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 22 | 47% |
Australia | 2 | 4% |
Spain | 1 | 2% |
Italy | 1 | 2% |
Canada | 1 | 2% |
India | 1 | 2% |
Denmark | 1 | 2% |
Brazil | 1 | 2% |
China | 1 | 2% |
Other | 1 | 2% |
Unknown | 15 | 32% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 19 | 40% |
Members of the public | 13 | 28% |
Practitioners (doctors, other healthcare professionals) | 13 | 28% |
Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 155 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 28 | 18% |
Student > Ph. D. Student | 23 | 15% |
Student > Bachelor | 14 | 9% |
Researcher | 12 | 8% |
Student > Doctoral Student | 9 | 6% |
Other | 21 | 14% |
Unknown | 48 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 26 | 17% |
Medicine and Dentistry | 25 | 16% |
Psychology | 22 | 14% |
Biochemistry, Genetics and Molecular Biology | 5 | 3% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 15 | 10% |
Unknown | 58 | 37% |