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Topoisomerase II regulates yeast genes with singular chromatin architectures

Overview of attention for article published in Nucleic Acids Research, August 2013
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Title
Topoisomerase II regulates yeast genes with singular chromatin architectures
Published in
Nucleic Acids Research, August 2013
DOI 10.1093/nar/gkt707
Pubmed ID
Authors

Christoforos Nikolaou, Ignacio Bermúdez, Chaysavanh Manichanh, José García-Martinez, Roderic Guigó, José E. Pérez-Ortín, Joaquim Roca

Abstract

Eukaryotic topoisomerase II (topo II) is the essential decatenase of newly replicated chromosomes and the main relaxase of nucleosomal DNA. Apart from these general tasks, topo II participates in more specialized functions. In mammals, topo IIα interacts with specific RNA polymerases and chromatin-remodeling complexes, whereas topo IIβ regulates developmental genes in conjunction with chromatin remodeling and heterochromatin transitions. Here we show that in budding yeast, topo II regulates the expression of specific gene subsets. To uncover this, we carried out a genomic transcription run-on shortly after the thermal inactivation of topo II. We identified a modest number of genes not involved in the general stress response but strictly dependent on topo II. These genes present distinctive functional and structural traits in comparison with the genome average. Yeast topo II is a positive regulator of genes with well-defined promoter architecture that associates to chromatin remodeling complexes; it is a negative regulator of genes extremely hypo-acetylated with complex promoters and undefined nucleosome positioning, many of which are involved in polyamine transport. These findings indicate that yeast topo II operates on singular chromatin architectures to activate or repress DNA transcription and that this activity produces functional responses to ensure chromatin stability.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 28%
Student > Ph. D. Student 9 25%
Student > Master 7 19%
Professor > Associate Professor 4 11%
Professor 2 6%
Other 4 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 53%
Agricultural and Biological Sciences 13 36%
Unspecified 2 6%
Physics and Astronomy 1 3%
Engineering 1 3%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2013.
All research outputs
#10,969,384
of 12,378,406 outputs
Outputs from Nucleic Acids Research
#19,274
of 20,537 outputs
Outputs of similar age
#129,936
of 154,726 outputs
Outputs of similar age from Nucleic Acids Research
#202
of 259 outputs
Altmetric has tracked 12,378,406 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 20,537 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 259 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.