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The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy

Overview of attention for article published in Nature Neuroscience, August 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Citations

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158 Dimensions

Readers on

mendeley
231 Mendeley
Title
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Published in
Nature Neuroscience, August 2013
DOI 10.1038/nn.3489
Pubmed ID
Authors

Victoria S Burchell, David E Nelson, Alvaro Sanchez-Martinez, Marta Delgado-Camprubi, Rachael M Ivatt, Joe H Pogson, Suzanne J Randle, Selina Wray, Patrick A Lewis, Henry Houlden, Andrey Y Abramov, John Hardy, Nicholas W Wood, Alexander J Whitworth, Heike Laman, Helene Plun-Favreau

Abstract

Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box domain-containing protein Fbxo7 (encoded by PARK15) also cause early-onset autosomal recessive Parkinson's disease, by an unknown mechanism. Here we show that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy. Cells with reduced Fbxo7 expression showed deficiencies in translocation of Parkin to mitochondria, ubiquitination of mitofusin 1 and mitophagy. In Drosophila, ectopic overexpression of Fbxo7 rescued loss of Parkin, supporting a functional relationship between the two proteins. Parkinson's disease-causing mutations in Fbxo7 interfered with this process, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 21 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 231 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
United Kingdom 4 2%
Brazil 1 <1%
Austria 1 <1%
Switzerland 1 <1%
Canada 1 <1%
Spain 1 <1%
Germany 1 <1%
Unknown 217 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 24%
Researcher 49 21%
Student > Master 31 13%
Student > Bachelor 31 13%
Student > Doctoral Student 10 4%
Other 39 17%
Unknown 15 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 101 44%
Biochemistry, Genetics and Molecular Biology 38 16%
Neuroscience 36 16%
Medicine and Dentistry 27 12%
Chemistry 2 <1%
Other 5 2%
Unknown 22 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 85. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2019.
All research outputs
#217,519
of 14,330,171 outputs
Outputs from Nature Neuroscience
#567
of 4,422 outputs
Outputs of similar age
#2,444
of 157,489 outputs
Outputs of similar age from Nature Neuroscience
#15
of 89 outputs
Altmetric has tracked 14,330,171 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,422 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 40.9. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,489 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.