Title |
Differential effects of natural rewards and pain on vesicular glutamate transporter expression in the nucleus accumbens
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Published in |
Molecular Brain, July 2013
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DOI | 10.1186/1756-6606-6-32 |
Pubmed ID | |
Authors |
David S Tukey, Michelle Lee, Duo Xu, Sarah E Eberle, Yossef Goffer, Toby R Manders, Edward B Ziff, Jing Wang |
Abstract |
Pain and natural rewards such as food elicit different behavioral effects. Both pain and rewards, however, have been shown to alter synaptic activities in the nucleus accumbens (NAc), a key component of the brain reward system. Mechanisms by which external stimuli regulate plasticity at NAc synapses are largely unexplored. Medium spiny neurons (MSNs) from the NAc receive excitatory glutamatergic inputs and modulatory dopaminergic and cholinergic inputs from a variety of cortical and subcortical structures. Glutamate inputs to the NAc arise primarily from prefrontal cortex, thalamus, amygdala, and hippocampus, and different glutamate projections provide distinct synaptic and ultimately behavioral functions. The family of vesicular glutamate transporters (VGLUTs 1-3) plays a key role in the uploading of glutamate into synaptic vesicles. VGLUT1-3 isoforms have distinct expression patterns in the brain, but the effects of external stimuli on their expression patterns have not been studied. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 5% |
Netherlands | 1 | 3% |
Unknown | 37 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 25% |
Researcher | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 4 | 10% |
Other | 3 | 8% |
Other | 10 | 25% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
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Neuroscience | 14 | 35% |
Agricultural and Biological Sciences | 10 | 25% |
Psychology | 5 | 13% |
Medicine and Dentistry | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 4 | 10% |