Title |
The interaction between gut microbiota and age-related changes in immune function and inflammation
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Published in |
Immunity & Ageing, August 2013
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DOI | 10.1186/1742-4933-10-31 |
Pubmed ID | |
Authors |
Thea Magrone, Emilio Jirillo |
Abstract |
Intestinal microbiota and gut immune systems interact each other, maintaining a condition of homeostasis in the context of the intestinal habitat. However, both systems undergo modifications in elderly, thus accounting for a low grade inflammatory status which, in turn, may evolve toward more severe pathological conditions such as inflammatory bowel disease and colon rectal cancer. In addition, in western societies dietary habits may negatively influence the microbiota composition, also altering gut immune response which is per se impaired in elderly. In order to prevent the outcome of aged-related disease, supplementation of nutraceuticals able to correct abnormalities of both immune system and microbiota has become more frequent than in the past. In this respect, a better identification of components of the aged microbiota as well as a deeper analysis of gut mucosal immunity function should be pursued. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 27% |
United States | 2 | 18% |
United Kingdom | 1 | 9% |
Netherlands | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 73% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
Malaysia | 1 | <1% |
Netherlands | 1 | <1% |
Colombia | 1 | <1% |
Brazil | 1 | <1% |
France | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 177 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 41 | 22% |
Student > Bachelor | 30 | 16% |
Student > Master | 23 | 12% |
Student > Ph. D. Student | 19 | 10% |
Student > Postgraduate | 8 | 4% |
Other | 40 | 22% |
Unknown | 25 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 28% |
Medicine and Dentistry | 33 | 18% |
Biochemistry, Genetics and Molecular Biology | 19 | 10% |
Immunology and Microbiology | 14 | 8% |
Nursing and Health Professions | 8 | 4% |
Other | 28 | 15% |
Unknown | 32 | 17% |