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Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta

Overview of attention for article published in Veterinary Research, August 2013
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Title
Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta
Published in
Veterinary Research, August 2013
DOI 10.1186/1297-9716-44-68
Pubmed ID
Authors

Anton Gossner, Hazel Wilkie, Anagha Joshi, John Hopkins

Abstract

This study exploited Blackface lambs that varied in their resistance to the abomasal nematode parasite, Teladorsagia circumcincta. Infection of these lambs over 3 months identified susceptible (high adult worm count, high faecal egg count and low IgA antibody) and resistant animals that had excluded all parasites. Previous work had shown that susceptibility and resistance is dependent on the differential immune response to the parasite, which occurs within the abomasal (gastric) lymph node (ALN) that drains the site of infection. The Affymetrix ovine gene array was used to interrogate the transcriptome of the ALN to identify genes and physiological pathways associated with resistance. We used a bovine RT-qPCR array of 84 genes to validate the gene array, and also report digital gene expression analysis on the same tissues, reanalysed using the Oar v3.1 sheep genome assembly. These analyses identified Humoral Immune Response, Protein Synthesis, Inflammatory Response and Hematological System Development and Function as the two top-ranked networks associated with resistance. Central genes within these networks were IL4, IL5, IL13RA2 and in particular IL13, which confirmed that differential activation of Th2 polarized responses is critical to the resistance phenotype. Furthermore, in resistant sheep there was up-regulation of genes linked to control and suppression of inflammation. The identity of differentially-expressed chemokines and receptors in the resistant and susceptible sheep also begins to explain the cellular nature of the host response to infection. This work will greatly help in the identification of candidate genes as potential selectable markers of genetic resistance.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 22%
Researcher 9 16%
Student > Master 7 13%
Student > Doctoral Student 7 13%
Student > Bachelor 3 5%
Other 10 18%
Unknown 7 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 45%
Veterinary Science and Veterinary Medicine 9 16%
Medicine and Dentistry 5 9%
Biochemistry, Genetics and Molecular Biology 5 9%
Unspecified 1 2%
Other 2 4%
Unknown 8 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Veterinary Research
#1,035
of 1,337 outputs
Outputs of similar age
#158,854
of 208,974 outputs
Outputs of similar age from Veterinary Research
#21
of 25 outputs
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