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Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent

Overview of attention for article published in American Journal of Human Genetics, August 2013
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
Published in
American Journal of Human Genetics, August 2013
DOI 10.1016/j.ajhg.2013.07.007
Pubmed ID
Authors

Teresa R. de Candia, S. Hong Lee, Jian Yang, Brian L. Browning, Pablo V. Gejman, Douglas F. Levinson, Bryan J. Mowry, John K. Hewitt, Michael E. Goddard, Michael C. O’Donovan, Shaun M. Purcell, Danielle Posthuma, the International Schizophrenia Consortium, the Molecular Genetics of Schizophrenia Collaboration, Peter M. Visscher, Naomi R. Wray, Matthew C. Keller

Abstract

To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European descent (ED [n = 4,990]) schizophrenia case-control genome-wide association study (GWAS) data set available, the Molecular Genetics of Schizophrenia (MGS) data set. We show how a method that uses genomic similarities at measured SNPs to estimate the additive genetic correlation (SNP correlation [SNP-rg]) between traits can be extended to estimate SNP-rg for the same trait between ethnicities. We estimated SNP-rg for schizophrenia between the MGS ED and MGS AD samples to be 0.66 (SE = 0.23), which is significantly different from 0 (p(SNP-rg = 0) = 0.0003), but not 1 (p(SNP-rg = 1) = 0.26). We re-estimated SNP-rg between an independent ED data set (n = 6,665) and the MGS AD sample to be 0.61 (SE = 0.21, p(SNP-rg = 0) = 0.0003, p(SNP-rg = 1) = 0.16). These results suggest that many schizophrenia risk alleles are shared across ethnic groups and predate African-European divergence.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 <1%
Luxembourg 1 <1%
Unknown 116 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 22%
Researcher 20 17%
Student > Master 12 10%
Student > Bachelor 11 9%
Student > Postgraduate 10 8%
Other 29 24%
Unknown 12 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 21%
Biochemistry, Genetics and Molecular Biology 18 15%
Medicine and Dentistry 18 15%
Psychology 14 12%
Social Sciences 5 4%
Other 24 20%
Unknown 16 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2023.
All research outputs
#4,523,911
of 25,373,627 outputs
Outputs from American Journal of Human Genetics
#2,142
of 5,878 outputs
Outputs of similar age
#36,358
of 207,678 outputs
Outputs of similar age from American Journal of Human Genetics
#30
of 51 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,878 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,678 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.