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p53 switches off pluripotency on differentiation

Overview of attention for article published in Stem Cell Research & Therapy, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
69 Mendeley
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Title
p53 switches off pluripotency on differentiation
Published in
Stem Cell Research & Therapy, February 2017
DOI 10.1186/s13287-017-0498-1
Pubmed ID
Authors

Tongxiang Lin, Yi Lin

Abstract

The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 protein, which plays a key role in embryonic stem cells, was first discovered in 2005. Landmark studies of p53-related reprogramming elucidated this protein's importance in induced pluripotent stem cells in 2009. The p53-related safety concerns in pluripotent stem cells have been raised in stem cell-based therapy although the use of iPSCs in therapeutic application is promising. Because cancer stem cells have profiles similar to those of pluripotent stem cells, we also describe potential strategies for studies in cancer stem cells and cancer treatments. The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 23%
Researcher 12 17%
Student > Bachelor 11 16%
Student > Master 7 10%
Student > Doctoral Student 6 9%
Other 7 10%
Unknown 10 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 36%
Agricultural and Biological Sciences 17 25%
Medicine and Dentistry 8 12%
Engineering 2 3%
Neuroscience 2 3%
Other 3 4%
Unknown 12 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#2,421,222
of 15,920,152 outputs
Outputs from Stem Cell Research & Therapy
#217
of 1,526 outputs
Outputs of similar age
#55,461
of 262,491 outputs
Outputs of similar age from Stem Cell Research & Therapy
#2
of 8 outputs
Altmetric has tracked 15,920,152 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,526 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,491 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.