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Nrf2 is required to maintain the self-renewal of glioma stem cells

Overview of attention for article published in BMC Cancer, August 2013
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2 tweeters

Citations

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35 Dimensions

Readers on

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44 Mendeley
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Title
Nrf2 is required to maintain the self-renewal of glioma stem cells
Published in
BMC Cancer, August 2013
DOI 10.1186/1471-2407-13-380
Pubmed ID
Authors

Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu, Mengliang Zhou

Abstract

Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioma stem cells (GSCs). Self-renewal is a complex biological process necessary for maintaining the glioma stem cells. Nuclear factor rythroid 2-related factor 2(Nrf2) plays a significant role in protecting cells from endogenous and exogenous stresses. Nrf2 is a key nuclear transcription factor that regulates antioxidant response element (ARE)-containing genes. Previous studies have demonstrated the significant role of Nrf2 in the proliferation of glioblastoma, and in their resistance to radioactive therapies. We examined the effect of knocking down Nrf2 in GSCs.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Brazil 1 2%
Portugal 1 2%
Unknown 40 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 34%
Researcher 8 18%
Unspecified 5 11%
Student > Doctoral Student 3 7%
Student > Postgraduate 3 7%
Other 10 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 32%
Medicine and Dentistry 10 23%
Unspecified 10 23%
Biochemistry, Genetics and Molecular Biology 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 4 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2013.
All research outputs
#4,606,545
of 6,229,091 outputs
Outputs from BMC Cancer
#1,947
of 3,060 outputs
Outputs of similar age
#67,716
of 100,671 outputs
Outputs of similar age from BMC Cancer
#36
of 57 outputs
Altmetric has tracked 6,229,091 research outputs across all sources so far. This one is in the 15th percentile – i.e., 15% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,060 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,671 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.