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Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

Overview of attention for article published in Clinical Epigenetics, January 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 591)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
facebook
2 Facebook pages
reddit
1 Redditor
q&a
1 Q&A thread

Citations

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100 Dimensions

Readers on

mendeley
52 Mendeley
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Title
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
Published in
Clinical Epigenetics, January 2011
DOI 10.1186/1868-7083-3-3
Pubmed ID
Authors

Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood, Emily Ho

Abstract

Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic marks, such as inhibition of histone deacetylase (HDAC) enzymes. However, the effects of SFN on other common epigenetic marks such as DNA methylation are understudied. Promoter hyper-methylation of cyclin D2, a major regulator of cell cycle, is correlated with prostate cancer progression, and restoration of cyclin D2 expression exerts anti-proliferative effects on LnCap prostate cancer cells. Our study aimed to investigate the effects of SFN on DNA methylation status of cyclin D2 promoter, and how alteration in promoter methylation impacts cyclin D2 gene expression in LnCap cells. We found that SFN significantly decreased the expression of DNA methyltransferases (DNMTs), especially DNMT1 and DNMT3b. Furthermore, SFN significantly decreased methylation in cyclin D2 promoter regions containing c-Myc and multiple Sp1 binding sites. Reduced methlyation of cyclin D2 promoter corresponded to an increase in cyclin D2 transcript levels, suggesting that SFN may de-repress methylation-silenced cyclin D2 by impacting epigenetic pathways. Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 27%
Student > Master 8 15%
Student > Ph. D. Student 7 13%
Student > Postgraduate 5 10%
Other 4 8%
Other 9 17%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 35%
Biochemistry, Genetics and Molecular Biology 12 23%
Medicine and Dentistry 8 15%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Nursing and Health Professions 2 4%
Other 4 8%
Unknown 5 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 March 2017.
All research outputs
#796,030
of 12,584,492 outputs
Outputs from Clinical Epigenetics
#40
of 591 outputs
Outputs of similar age
#9,533
of 124,962 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 3 outputs
Altmetric has tracked 12,584,492 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 591 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,962 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them