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Modeling Peptide-Protein Interactions

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Cover of 'Modeling Peptide-Protein Interactions'

Table of Contents

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    Book Overview
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    Chapter 1 The Usage of ACCLUSTER for Peptide Binding Site Prediction
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    Chapter 2 Detection of Peptide-Binding Sites on Protein Surfaces Using the Peptimap Server
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    Chapter 3 Peptide Suboptimal Conformation Sampling for the Prediction of Protein-Peptide Interactions
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    Chapter 4 Template-Based Prediction of Protein-Peptide Interactions by Using GalaxyPepDock
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    Chapter 5 Application of the ATTRACT Coarse-Grained Docking and Atomistic Refinement for Predicting Peptide-Protein Interactions
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    Chapter 6 Highly Flexible Protein-Peptide Docking Using CABS-Dock
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    Chapter 7 AnchorDock for Blind Flexible Docking of Peptides to Proteins
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    Chapter 8 Information-Driven, Ensemble Flexible Peptide Docking Using HADDOCK
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    Chapter 9 Modeling Peptide-Protein Structure and Binding Using Monte Carlo Sampling Approaches: Rosetta FlexPepDock and FlexPepBind
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    Chapter 10 Flexible Backbone Methods for Predicting and Designing Peptide Specificity
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    Chapter 11 Simplifying the Design of Protein-Peptide Interaction Specificity with Sequence-Based Representations of Atomistic Models
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    Chapter 12 Binding Specificity Profiles from Computational Peptide Screening
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    Chapter 13 Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design
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    Chapter 14 Investigating Protein–Peptide Interactions Using the Schrödinger Computational Suite
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    Chapter 15 Identifying Loop-Mediated Protein–Protein Interactions Using LoopFinder
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    Chapter 16 Protein-Peptide Interaction Design: PepCrawler and PinaColada
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    Chapter 17 Modeling and Design of Peptidomimetics to Modulate Protein–Protein Interactions
Attention for Chapter 17: Modeling and Design of Peptidomimetics to Modulate Protein–Protein Interactions
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Chapter title
Modeling and Design of Peptidomimetics to Modulate Protein–Protein Interactions
Chapter number 17
Book title
Modeling Peptide-Protein Interactions
Published in
Methods in molecular biology, February 2017
DOI 10.1007/978-1-4939-6798-8_17
Pubmed ID
Book ISBNs
978-1-4939-6796-4, 978-1-4939-6798-8
Authors

Andrew M. Watkins, Richard Bonneau, Paramjit S. Arora

Editors

Ora Schueler-Furman, Nir London

Abstract

We describe a modular approach to identify and inhibit protein-protein interactions (PPIs) that are mediated by protein secondary and tertiary structures with rationally designed peptidomimetics. Our analysis begins with entries of high-resolution complexes in the Protein Data Bank and utilizes conformational sampling, scoring, and design capabilities of advanced biomolecular modeling software to develop peptidomimetics.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Professor 2 20%
Student > Bachelor 2 20%
Professor > Associate Professor 2 20%
Other 1 10%
Student > Postgraduate 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 20%
Biochemistry, Genetics and Molecular Biology 2 20%
Agricultural and Biological Sciences 2 20%
Neuroscience 1 10%
Chemistry 1 10%
Other 0 0%
Unknown 2 20%