Title |
Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington’s disease monkeys
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Published in |
BMC Neuroscience, August 2013
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DOI | 10.1186/1471-2202-14-88 |
Pubmed ID | |
Authors |
Jannet Kocerha, Yuhong Liu, David Willoughby, Kumaravel Chidamparam, Joseph Benito, Kate Nelson, Yan Xu, Tim Chi, Heidi Engelhardt, Sean Moran, Shang-Hsun Yang, Shi-Hua Li, Xiao-Jiang Li, Katherine Larkin, Adam Neumann, Heather Banta, Jin Jing Yang, Anthony WS Chan |
Abstract |
Huntington's Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enables distinct disease-associated mechanisms to be identified. |
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Mendeley readers
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Researcher | 5 | 14% |
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Unknown | 9 | 26% |