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Higher BMP/Smad sensitivity of tendon-derived stem cells (TDSCs) isolated from the collagenase-induced tendon injury model: possible mechanism for their altered fate in vitro

Overview of attention for article published in BMC Musculoskeletal Disorders, August 2013
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Title
Higher BMP/Smad sensitivity of tendon-derived stem cells (TDSCs) isolated from the collagenase-induced tendon injury model: possible mechanism for their altered fate in vitro
Published in
BMC Musculoskeletal Disorders, August 2013
DOI 10.1186/1471-2474-14-248
Pubmed ID
Authors

Pauline Po Yee Lui, Yin Mei Wong

Abstract

Ectopic expression of BMP-2, BMP-4 and BMP-7 was observed in clinical samples of tendinopathy and collagenase-induced (CI) tendon injury rat model. TDSCs isolated from the CI model showed increased non-tenogenic differentiation potential and hence altered fate compared to the TDSCs isolated from the healthy animals (HT) but the mechanism is unclear. We hypothesized that sensitization of the BMP/Smad pathway in TDSCs (CI) might account for this difference. This study aimed to compare the activation state of the BMP/Smad pathway at basal level and upon BMP-2 stimulation in TDSCs (CI) and TDSCs (HT).

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 29%
Student > Master 6 25%
Researcher 2 8%
Student > Doctoral Student 2 8%
Student > Bachelor 1 4%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 11 46%
Agricultural and Biological Sciences 4 17%
Engineering 2 8%
Sports and Recreations 2 8%
Nursing and Health Professions 1 4%
Other 2 8%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2013.
All research outputs
#3,555,337
of 5,036,908 outputs
Outputs from BMC Musculoskeletal Disorders
#1,405
of 1,695 outputs
Outputs of similar age
#65,884
of 97,769 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#52
of 53 outputs
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We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.