The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

https://t.co/munowHAORg "extracellular succinate, through action of the succinate receptor, triggers the increased expression and release of VEGF under hypoxic conditions, independently from HIF1α."

https://t.co/munowHAORg "Succinate treatment of the DCs promoted the interferon-γ production of activated CD4+ T-cells."

https://t.co/munowHAORg "In SUCNR1-positive adipocytes, succinate inhibits lipolysis (Regard et al., 2008) and may thus prevent the release of fatty acids from adipocyte for energy consumption."

https://t.co/munowHAORg "As such, in situations when pO2 is low, succinate will accumulate due to low activity of succinate dehydrogenase or other enzymes in the electron transport chain that affect its activity"