Title |
Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion‐dependent thalassaemia
|
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Published in |
Cochrane database of systematic reviews, August 2013
|
DOI | 10.1002/14651858.cd004450.pub3 |
Pubmed ID | |
Authors |
Sheila A Fisher, Susan J Brunskill, Carolyn Doree, Sarah Gooding, Onima Chowdhury, David J Roberts |
Abstract |
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions.Repeated transfusions result in an excessive accumulation of iron in the body (iron overload), removal of which is achieved through iron chelation therapy. Desferrioxamine mesylate (desferrioxamine) is one of the most widely used iron chelators. Substantial data have shown the beneficial effects of desferrioxamine, although adherence to desferrioxamine therapy is a challenge. Alternative oral iron chelators, deferiprone and deferasirox, are now commonly used. Important questions exist about whether desferrioxamine, as monotherapy or in combination with an oral iron chelator, is the best treatment for iron chelation therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
Germany | 2 | <1% |
Indonesia | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 295 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 55 | 18% |
Researcher | 38 | 13% |
Student > Bachelor | 35 | 12% |
Student > Ph. D. Student | 28 | 9% |
Student > Doctoral Student | 19 | 6% |
Other | 59 | 20% |
Unknown | 67 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 103 | 34% |
Nursing and Health Professions | 31 | 10% |
Psychology | 18 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 4% |
Agricultural and Biological Sciences | 10 | 3% |
Other | 43 | 14% |
Unknown | 84 | 28% |