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Chapter title |
Measurement of Lytic Granule Convergence After Formation of an NK Cell Immunological Synapse
|
---|---|
Chapter number | 31 |
Book title |
The Immune Synapse
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Published in |
Methods in molecular biology, March 2017
|
DOI | 10.1007/978-1-4939-6881-7_31 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6879-4, 978-1-4939-6881-7
|
Authors |
Hsiang-Ting Hsu, Alexandre F. Carisey, Jordan S. Orange |
Editors |
Cosima T. Baldari, Michael L. Dustin |
Abstract |
Natural killer (NK) cells contain specialized lysosome-related organelles termed lytic granules allowing them to mediate cytotoxicity against tumorigenic or virally infected target cells. NK cells polarize their lytic granules toward a target cell via the microtubule-organizing center (MTOC). Prior to that, however, lytic granules converge to the MTOC along microtubules utilizing minus-end-directed microtubule motors. Herein we describe how to visualize and quantify lytic granule convergence using confocal microscopy to gain quantitative insight into NK cell cytotoxicity and its regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 25% |
Other | 2 | 13% |
Professor > Associate Professor | 2 | 13% |
Professor | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 13% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 3 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Engineering | 2 | 13% |
Medicine and Dentistry | 2 | 13% |
Earth and Planetary Sciences | 1 | 6% |
Other | 2 | 13% |
Unknown | 4 | 25% |