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Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells

Overview of attention for article published in Journal of Cellular and Molecular Medicine, February 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

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2 tweeters
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2 Facebook pages

Citations

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18 Dimensions

Readers on

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19 Mendeley
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Title
Extracellular histones disarrange vasoactive mediators release through a COX-NOS interaction in human endothelial cells
Published in
Journal of Cellular and Molecular Medicine, February 2017
DOI 10.1111/jcmm.13088
Pubmed ID
Authors

Daniel Pérez-Cremades, Carlos Bueno-Betí, José Luis García-Giménez, José Santiago Ibañez-Cabellos, Carlos Hermenegildo, Federico V. Pallardó, Susana Novella

Abstract

Extracellular histones are mediators of inflammation, tissue injury and organ dysfunction. Interactions between circulating histones and vascular endothelial cells are key events in histone-mediated pathologies. Our aim was to investigate the implication of extracellular histones in the production of the major vasoactive compounds released by human endothelial cells (HUVECs), prostanoids and nitric oxide (NO). HUVEC exposed to increasing concentrations of histones (0.001 to 100 μg/ml) for 4 hrs induced prostacyclin (PGI2) production in a dose-dependent manner and decreased thromboxane A2 (TXA2) release at 100 μg/ml. Extracellular histones raised cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS) mRNA and protein expression, decreased COX-1 mRNA levels and did not change thromboxane A2 synthase (TXAS) expression. Moreover, extracellular histones decreased both, eNOS expression and NO production in HUVEC. The impaired NO production was related to COX-2 activity and superoxide production since was reversed after celecoxib (10 μmol/l) and tempol (100 μmol/l) treatments, respectively. In conclusion, our findings suggest that extracellular histones stimulate the release of endothelial-dependent mediators through an up-regulation in COX-2-PGIS-PGI2 pathway which involves a COX-2-dependent superoxide production that decreases the activity of eNOS and the NO production. These effects may contribute to the endothelial cell dysfunction observed in histone-mediated pathologies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 53%
Student > Ph. D. Student 3 16%
Student > Bachelor 1 5%
Student > Doctoral Student 1 5%
Student > Master 1 5%
Other 1 5%
Unknown 2 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 53%
Medicine and Dentistry 2 11%
Agricultural and Biological Sciences 1 5%
Earth and Planetary Sciences 1 5%
Unspecified 1 5%
Other 0 0%
Unknown 4 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2017.
All research outputs
#6,759,461
of 12,471,795 outputs
Outputs from Journal of Cellular and Molecular Medicine
#707
of 1,598 outputs
Outputs of similar age
#111,586
of 251,838 outputs
Outputs of similar age from Journal of Cellular and Molecular Medicine
#17
of 61 outputs
Altmetric has tracked 12,471,795 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,598 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,838 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.