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GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics

Overview of attention for article published in Human Molecular Genetics, August 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
2 tweeters
patent
1 patent
reddit
1 Redditor

Citations

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33 Dimensions

Readers on

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74 Mendeley
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Title
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics
Published in
Human Molecular Genetics, August 2013
DOI 10.1093/hmg/ddt404
Pubmed ID
Authors

Mirko Ledda, Zoltán Kutalik, Maria C. Souza Destito, Milena M. Souza, Cintia A. Cirillo, Amabilene Zamboni, Nathalie Martin, Edgard Morya, Koichi Sameshima, Jacques S. Beckmann, Johannes le Coutre, Sven Bergmann, Ulrich K. Genick

Abstract

Human perception of bitterness displays pronounced interindividual variation. This phenotypic variation is mirrored by equally pronounced genetic variation in the family of bitter taste receptor genes. To better understand the effects of common genetic variations on human bitter taste perception, we conducted a genome-wide association study on a discovery panel of 504 subjects and a validation panel of 104 subjects from the general population of São Paulo in Brazil. Correction for general taste-sensitivity allowed us to identify a SNP in the cluster of bitter taste receptors on chr12 (10.88- 11.24 Mb, build 36.1) significantly associated (best SNP: rs2708377, P = 5.31 × 10(-13), r(2) = 8.9%, β = -0.12, s.e. = 0.016) with the perceived bitterness of caffeine. This association overlaps with-but is statistically distinct from-the previously identified SNP rs10772420 influencing the perception of quinine bitterness that falls in the same bitter taste cluster. We replicated this association to quinine perception (P = 4.97 × 10(-37), r(2) = 23.2%, β = 0.25, s.e. = 0.020) and additionally found the effect of this genetic locus to be concentration specific with a strong impact on the perception of low, but no impact on the perception of high concentrations of quinine. Our study, thus, furthers our understanding of the complex genetic architecture of bitter taste perception.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 3%
Denmark 2 3%
United Kingdom 1 1%
Netherlands 1 1%
United States 1 1%
Unknown 67 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 27%
Student > Ph. D. Student 16 22%
Student > Master 8 11%
Student > Bachelor 6 8%
Professor 5 7%
Other 12 16%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 42%
Biochemistry, Genetics and Molecular Biology 11 15%
Medicine and Dentistry 7 9%
Chemistry 3 4%
Psychology 2 3%
Other 7 9%
Unknown 13 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2018.
All research outputs
#3,171,710
of 12,510,237 outputs
Outputs from Human Molecular Genetics
#2,190
of 6,310 outputs
Outputs of similar age
#37,099
of 154,671 outputs
Outputs of similar age from Human Molecular Genetics
#20
of 71 outputs
Altmetric has tracked 12,510,237 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 6,310 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,671 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.