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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vitamin B6 reduces hippocampal apoptosis in experimental pneumococcal meningitis
|
|---|---|
| Published in |
BMC Infectious Diseases, August 2013
|
| DOI | 10.1186/1471-2334-13-393 |
| Pubmed ID | |
| Authors |
Denise C Zysset-Burri, Caroline L Bellac, Stephen L Leib, Matthias Wittwer |
| Abstract |
Bacterial meningitis caused by Streptococcus pneumoniae leads to death in up to 30% of patients and leaves up to half of the survivors with neurological sequelae. The inflammatory host reaction initiates the induction of the kynurenine pathway and contributes to hippocampal apoptosis, a form of brain damage that is associated with learning and memory deficits in experimental paradigms. Vitamin B6 is an enzymatic cofactor in the kynurenine pathway and may thus limit the accumulation of neurotoxic metabolites and preserve the cellular energy status. The aim of this study in a pneumococcal meningitis model was to investigate the effect of vitamin B6 on hippocampal apoptosis by histomorphology, by transcriptomics and by measurement of cellular nicotine amide adenine dinucleotide content. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Canada | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 17% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 5 | 11% |
| Student > Bachelor | 5 | 11% |
| Student > Master | 5 | 11% |
| Other | 8 | 17% |
| Unknown | 10 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 15% |
| Medicine and Dentistry | 7 | 15% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Agricultural and Biological Sciences | 4 | 9% |
| Psychology | 3 | 7% |
| Other | 9 | 20% |
| Unknown | 11 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2022.
All research outputs
#13,694,096
of 22,719,618 outputs
Outputs from BMC Infectious Diseases
#3,473
of 7,658 outputs
Outputs of similar age
#108,457
of 200,133 outputs
Outputs of similar age from BMC Infectious Diseases
#58
of 152 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 38th percentile – i.e., 38% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,658 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,133 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.