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Cerebral organoids model human brain development and microcephaly

Overview of attention for article published in Nature, August 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
2586 Mendeley
citeulike
11 CiteULike
Title
Cerebral organoids model human brain development and microcephaly
Published in
Nature, August 2013
DOI 10.1038/nature12517
Pubmed ID
Authors

Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, Juergen A. Knoblich, Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA

Abstract

The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes. Furthermore, cerebral organoids are shown to recapitulate features of human cortical development, namely characteristic progenitor zone organization with abundant outer radial glial stem cells. Finally, we use RNA interference and patient-specific induced pluripotent stem cells to model microcephaly, a disorder that has been difficult to recapitulate in mice. We demonstrate premature neuronal differentiation in patient organoids, a defect that could help to explain the disease phenotype. Together, these data show that three-dimensional organoids can recapitulate development and disease even in this most complex human tissue.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 2,586 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 63 2%
United Kingdom 27 1%
Germany 19 <1%
France 14 <1%
Japan 13 <1%
Spain 10 <1%
Brazil 9 <1%
Netherlands 9 <1%
Australia 8 <1%
Other 53 2%
Unknown 2361 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 682 26%
Researcher 543 21%
Student > Bachelor 383 15%
Student > Master 371 14%
Student > Doctoral Student 130 5%
Other 477 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 1159 45%
Biochemistry, Genetics and Molecular Biology 394 15%
Neuroscience 274 11%
Medicine and Dentistry 247 10%
Engineering 176 7%
Other 336 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1420. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2018.
All research outputs
#1,194
of 11,497,259 outputs
Outputs from Nature
#227
of 59,507 outputs
Outputs of similar age
#18
of 141,075 outputs
Outputs of similar age from Nature
#6
of 975 outputs
Altmetric has tracked 11,497,259 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 59,507 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 71.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,075 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 975 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.