↓ Skip to main content

Cerebral organoids model human brain development and microcephaly

Overview of attention for article published in Nature, August 2013
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Citations

dimensions_citation
1278 Dimensions

Readers on

mendeley
3172 Mendeley
citeulike
11 CiteULike
Title
Cerebral organoids model human brain development and microcephaly
Published in
Nature, August 2013
DOI 10.1038/nature12517
Pubmed ID
Authors

Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, Juergen A. Knoblich

Abstract

The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subtypes. Furthermore, cerebral organoids are shown to recapitulate features of human cortical development, namely characteristic progenitor zone organization with abundant outer radial glial stem cells. Finally, we use RNA interference and patient-specific induced pluripotent stem cells to model microcephaly, a disorder that has been difficult to recapitulate in mice. We demonstrate premature neuronal differentiation in patient organoids, a defect that could help to explain the disease phenotype. Together, these data show that three-dimensional organoids can recapitulate development and disease even in this most complex human tissue.

Twitter Demographics

The data shown below were collected from the profiles of 658 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 3,172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 64 2%
United Kingdom 26 <1%
Germany 18 <1%
Japan 13 <1%
Netherlands 11 <1%
France 11 <1%
Spain 9 <1%
Brazil 8 <1%
Australia 8 <1%
Other 53 2%
Unknown 2951 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 823 26%
Researcher 639 20%
Student > Bachelor 470 15%
Student > Master 445 14%
Unspecified 159 5%
Other 636 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 1231 39%
Biochemistry, Genetics and Molecular Biology 563 18%
Neuroscience 372 12%
Medicine and Dentistry 287 9%
Unspecified 230 7%
Other 489 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1469. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2019.
All research outputs
#1,538
of 13,129,543 outputs
Outputs from Nature
#269
of 68,669 outputs
Outputs of similar age
#19
of 157,338 outputs
Outputs of similar age from Nature
#6
of 1,084 outputs
Altmetric has tracked 13,129,543 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 68,669 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,084 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.