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Mst1 and Mst2 kinases: regulations and diseases

Overview of attention for article published in Cell & Bioscience, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 163)
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

dimensions_citation
42 Dimensions

Readers on

mendeley
97 Mendeley
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Title
Mst1 and Mst2 kinases: regulations and diseases
Published in
Cell & Bioscience, August 2013
DOI 10.1186/2045-3701-3-31
Pubmed ID
Authors

Funiu Qin, Funiu Qin, Jing Tian, Dawang Zhou, Lanfen Chen

Abstract

The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development. Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2. As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them. Generally, loss of both Mst1 and Mst2 results in hyperproliferation and tumorigenesis that can be largely negated by the reduction or elimination of YAP. The Hippo pathway integrates with other signaling pathways e.g. Wnt and Notch pathways and coordinates with them to impact on the tumor pathogenesis and development. Furthermore, Mst1/2 kinases also act as an important regulator in immune cell activation, adhesion, migration, growth, and apoptosis. This review will focus on the recent updates on those aspects for the roles of Mst1/2 kinases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Portugal 1 1%
Korea, Republic of 1 1%
Canada 1 1%
Unknown 93 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 24%
Student > Master 15 15%
Researcher 15 15%
Student > Bachelor 14 14%
Student > Doctoral Student 8 8%
Other 19 20%
Unknown 3 3%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 31 32%
Agricultural and Biological Sciences 29 30%
Medicine and Dentistry 13 13%
Immunology and Microbiology 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 10 10%
Unknown 5 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2015.
All research outputs
#1,466,151
of 6,803,403 outputs
Outputs from Cell & Bioscience
#24
of 163 outputs
Outputs of similar age
#28,839
of 126,896 outputs
Outputs of similar age from Cell & Bioscience
#1
of 5 outputs
Altmetric has tracked 6,803,403 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 163 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,896 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them