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Mst1 and Mst2 kinases: regulations and diseases

Overview of attention for article published in Cell & Bioscience, August 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

wikipedia
3 Wikipedia pages

Citations

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76 Dimensions

Readers on

mendeley
153 Mendeley
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Title
Mst1 and Mst2 kinases: regulations and diseases
Published in
Cell & Bioscience, August 2013
DOI 10.1186/2045-3701-3-31
Pubmed ID
Authors

Funiu Qin, Jing Tian, Dawang Zhou, Lanfen Chen

Abstract

The Hippo signaling pathway has emerged as a critical regulator for organ size control. The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development. Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2. As in Drosophila, murine Mst1/Mst2, in a redundant manner, negatively regulate the Yorkie ortholog YAP in multiple organs, although considerable diversification in the pathway composition and regulation is observed in some of them. Generally, loss of both Mst1 and Mst2 results in hyperproliferation and tumorigenesis that can be largely negated by the reduction or elimination of YAP. The Hippo pathway integrates with other signaling pathways e.g. Wnt and Notch pathways and coordinates with them to impact on the tumor pathogenesis and development. Furthermore, Mst1/2 kinases also act as an important regulator in immune cell activation, adhesion, migration, growth, and apoptosis. This review will focus on the recent updates on those aspects for the roles of Mst1/2 kinases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Portugal 1 <1%
Korea, Republic of 1 <1%
Canada 1 <1%
Unknown 149 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 30 20%
Student > Master 25 16%
Researcher 21 14%
Student > Bachelor 21 14%
Student > Doctoral Student 9 6%
Other 27 18%
Unknown 20 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 52 34%
Agricultural and Biological Sciences 32 21%
Medicine and Dentistry 13 8%
Immunology and Microbiology 9 6%
Chemistry 7 5%
Other 14 9%
Unknown 26 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2021.
All research outputs
#7,500,672
of 23,577,654 outputs
Outputs from Cell & Bioscience
#176
of 1,002 outputs
Outputs of similar age
#64,930
of 201,790 outputs
Outputs of similar age from Cell & Bioscience
#1
of 4 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,002 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 201,790 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them