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Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.

Overview of attention for article published in Cell & Bioscience, August 2013
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Title
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.
Published in
Cell & Bioscience, August 2013
DOI 10.1186/2045-3701-3-32
Pubmed ID
Abstract

The metazoan Hippo pathway is an essential tumour suppressor signalling cascade that ensures normal tissue growth by co-ordinating cell proliferation, cell death and cell differentiation. Over the past years, various genetic and biochemical studies in Drosophila and mammals have defined a conserved core Hippo signalling module, composed of members of the Ste20-like kinase, the MOB co-activator and the AGC kinase families. In Drosophila, stimulated Hippo kinase phosphorylates and thereby activates the Mats/Warts complex, which consequently phosphorylates and inactivates the transcriptional co-activator Yorkie. In mammals, the counterparts of the Hippo/Mats/Warts/Yorkie cascade, namely MST1/2, MOB1A/B, LATS1/2 and YAP/TAZ, function in a similar fashion. These canonical Hippo pathways are so highly conserved that human MST2, hMOB1A and LATS1 can compensate for the loss of Hippo, Mats and Warts in flies. However, recent reports have shown that Hippo signalling is more diverse and complex, in particular in mammals. In this review, we summarize our current understanding of mammalian LATS1/2 kinases together with their closest relatives, the NDR1/2 kinases. The regulation of the LATS/NDR family of kinases will be discussed, followed by a summary of all currently known LATS/NDR substrates. Last, but not least, the biological roles of LATS/NDR kinases will be reviewed with specific emphasis on recent discoveries of canonical and non-canonical LATS/NDR functions in the extended Hippo pathway.

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Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 2%
Portugal 1 <1%
United States 1 <1%
Unknown 98 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 25%
Student > Ph. D. Student 22 22%
Student > Master 15 15%
Professor > Associate Professor 9 9%
Student > Bachelor 7 7%
Other 17 17%
Unknown 7 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 41 40%
Agricultural and Biological Sciences 40 39%
Neuroscience 4 4%
Medicine and Dentistry 3 3%
Chemistry 2 2%
Other 3 3%
Unknown 9 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2013.
All research outputs
#2,902,181
of 3,636,263 outputs
Outputs from Cell & Bioscience
#47
of 60 outputs
Outputs of similar age
#70,131
of 88,351 outputs
Outputs of similar age from Cell & Bioscience
#3
of 4 outputs
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