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Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity

Overview of attention for article published in Molecules, March 2017
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Title
Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity
Published in
Molecules, March 2017
DOI 10.3390/molecules22030444
Pubmed ID
Authors

Li-Hong Huang, Yan-Xiu Chen, Jian-Chen Yu, Jie Yuan, Hou-Jin Li, Wen-Zhe Ma, Ramida Watanapokasin, Kun-Chao Hu, Shah Niaz, De-Po Yang, Wen-Jian Lan

Abstract

Bioassay-guided isolation of the secondary metabolites from the fungus Dichotomomyces sp. L-8 associated with the soft coral Lobophytum crassum led to the discovery of two new compounds, dichotones A and B (1 and 2), together with four known compounds including dichotocejpin C (3), bis-N-norgliovictin (4), bassiatin (5) and (3R,6R)-bassiatin (6). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3R,6R)-bassiatin (6) displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC50 values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (5), the diastereomer of compound 6, was not cytotoxic.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 27%
Professor 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Student > Master 1 9%
Other 1 9%
Unknown 1 9%
Readers by discipline Count As %
Chemistry 4 36%
Agricultural and Biological Sciences 2 18%
Biochemistry, Genetics and Molecular Biology 2 18%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2017.
All research outputs
#7,507,337
of 9,727,924 outputs
Outputs from Molecules
#2,676
of 4,912 outputs
Outputs of similar age
#186,174
of 255,321 outputs
Outputs of similar age from Molecules
#235
of 426 outputs
Altmetric has tracked 9,727,924 research outputs across all sources so far. This one is in the 12th percentile – i.e., 12% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,912 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 426 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.