↓ Skip to main content

Chemopreventive Effects of Germinated Rough Rice Crude Extract in Inhibiting Azoxymethane‐Induced Aberrant Crypt Foci Formation in Sprague-Dawley Rats

Overview of attention for article published in BioMed Research International, January 2017
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
25 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Chemopreventive Effects of Germinated Rough Rice Crude Extract in Inhibiting Azoxymethane‐Induced Aberrant Crypt Foci Formation in Sprague-Dawley Rats
Published in
BioMed Research International, January 2017
DOI 10.1155/2017/9517287
Pubmed ID
Authors

Elnaz Saki, Latifah Saiful Yazan, Razana Mohd Ali, Zalinah Ahmad

Abstract

Chemoprevention has become an important area in cancer research due to low success rate of current therapeutic modalities. Diet plays a vital role in the etiology of cancer. This research was carried out to study the chemopreventive properties of germinated rough rice (GRR) crude extract in Sprague-Dawley rats induced with azoxymethane. Germination of rough rice causes significant changes in several chemical compositions of presently bioactive compounds. These compounds may prevent or postpone the inception of cancer. Fifty male Sprague-Dawley rats (6 weeks of age) were randomly divided into 5 groups which were (G1) induced with azoxymethane (AOM) and not given GRR (positive control), (G2) induced with AOM and given 2000 mg/kg GRR, (G3) induced with AOM and given 1000 mg/kg GRR, (G4) induced with AOM and given 500 mg/kg GRR, and (G5) not induced with AOM and not given GRR crude extract (negative control). To induce colon cancer, rats received two IP injections of AOM in saline (15 mg/kg) for two subsequent weeks. Organs were removed and weighed. Aberrant crypt foci (ACF) were evaluated histopathologically. β-Catenin expressions were determined by Western blot. Treatment with 2000 mg/kg GRR crude extract not only resulted in the greatest reduction in the size and number of ACF but also displayed the highest percentage of nondysplastic ACF. Treatment with 2000 mg/kg GRR also gave the lowest level of expression in β-catenin. Thus, GRR could be a promising dietary supplement for prevention of CRC.

Timeline

Login to access the full chart related to this output.

If you don’t have an account, click here to discover Explorer

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 28%
Student > Ph. D. Student 5 20%
Student > Master 3 12%
Lecturer 1 4%
Professor > Associate Professor 1 4%
Other 1 4%
Unknown 7 28%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 24%
Biochemistry, Genetics and Molecular Biology 6 24%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Medicine and Dentistry 2 8%
Psychology 1 4%
Other 1 4%
Unknown 7 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2017.
All research outputs
#20,950,527
of 25,732,188 outputs
Outputs from BioMed Research International
#6,895
of 10,824 outputs
Outputs of similar age
#322,599
of 423,942 outputs
Outputs of similar age from BioMed Research International
#161
of 202 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,824 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,942 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 202 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.