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X Demographics
Mendeley readers
| Title |
Selenium supplementation for patients with Graves’ hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial
|
|---|---|
| Published in |
Trials, April 2013
|
| DOI | 10.1186/1745-6215-14-119 |
| Pubmed ID | |
| Authors |
Torquil Watt, Per Cramon, Jakob Bue Bjorner, Steen Joop Bonnema, Ulla Feldt-Rasmussen, Christian Gluud, Jeppe Gram, Jane Lindschou Hansen, Laszlo Hegedüs, Nils Knudsen, Pernille Bach-Mortensen, Runa Nolsøe, Birte Nygaard, Flemming Pociot, Maria Skoog, Per Winkel, Åse Krogh Rasmussen |
| Abstract |
Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmune hypothyroidism and on Graves' orbitopathy, but the effects of selenium on Graves' hyperthyroidism is unknown.We hypothesize that adjuvant selenium may be beneficial in the treatment of Graves' hyperthyroidism. The objective is to investigate if selenium supplementation plus standard treatment with anti-thyroid drugs versus standard treatment with anti-thyroid drugs will lead to a decrease in anti-thyroid drug treatment failure (that is, failure to remain euthyroid, without further treatment, one year after cessation of anti-thyroid drug treatment), faster and longer lasting remission (that is, anti-thyroid drug treatment success), and improved quality of life in patients with Graves' hyperthyroidism. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Ecuador | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 159 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 17% |
| Student > Bachelor | 23 | 14% |
| Researcher | 19 | 12% |
| Student > Ph. D. Student | 13 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 25 | 15% |
| Unknown | 43 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 31% |
| Nursing and Health Professions | 24 | 15% |
| Agricultural and Biological Sciences | 14 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Psychology | 5 | 3% |
| Other | 17 | 10% |
| Unknown | 46 | 28% |