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Prokaryotic Cytoskeletons

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Attention for Chapter 2: E. coli Cell Cycle Machinery
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Chapter title
E. coli Cell Cycle Machinery
Chapter number 2
Book title
Prokaryotic Cytoskeletons
Published in
Sub cellular biochemistry, May 2017
DOI 10.1007/978-3-319-53047-5_2
Pubmed ID
Book ISBNs
978-3-31-953045-1, 978-3-31-953047-5

Joe Lutkenhaus, Shishen Du


Jan Löwe, Linda A. Amos


Cytokinesis in E. coli is organized by a cytoskeletal element designated the Z ring. The Z ring is formed at midcell by the coalescence of FtsZ filaments tethered to the membrane by interaction of FtsZ's conserved C-terminal peptide (CCTP) with two membrane-associated proteins, FtsA and ZipA. Although interaction between an FtsZ monomer and either of these proteins is of low affinity, high affinity is achieved through avidity - polymerization linked CCTPs interacting with the membrane tethers. The placement of the Z ring at midcell is ensured by antagonists of FtsZ polymerization that are positioned within the cell and target FtsZ filaments through the CCTP. The placement of the ring is reinforced by a protein network that extends from the terminus (Ter) region of the chromosome to the Z ring. Once the Z ring is established, additional proteins are recruited through interaction with FtsA, to form the divisome. The assembled divisome is then activated by FtsN to carry out septal peptidoglycan synthesis, with a dynamic Z ring serving as a guide for septum formation. As the septum forms, the cell wall is split by spatially regulated hydrolases and the outer membrane invaginates in step with the aid of a transenvelope complex to yield progeny cells.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 25%
Student > Bachelor 5 21%
Student > Doctoral Student 3 13%
Researcher 3 13%
Professor 1 4%
Other 2 8%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 50%
Immunology and Microbiology 3 13%
Agricultural and Biological Sciences 3 13%
Physics and Astronomy 1 4%
Engineering 1 4%
Other 0 0%
Unknown 4 17%